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Attempts are being made to develop drugs that act as CR mimetics, and much of that work has focused on a class of proteins called sirtuins.[100] Resveratrol has been reported to activate SIRT1 and extend the lifespan of yeast,[101] nematode worms, fruit flies,[102] vertebrate fish,[103] and mice consuming a high-caloric diet.[104] However, resveratrol does not extend life span in normal mice[105] and the effect of resveratrol on lifespan in nematodes and fruit flies has been disputed.[106] There are studies that indicate that resveratrol may not function through SIRT1[107][108] but may work through other targets.[109][110] A clinical trial of the resveratrol formulation SRT501 was suspended.[111] There is some evidence from mice that caloric restriction may be mediated through SIRT3[112] or SIRT6.[113] |
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