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People suffering from a rare condition known as Laron syndrome have a mutation in the gene that makes the receptor for growth hormone. It is theorised that this mutation may hold a key to life extension. Longo said that some level of IGF-1 was necessary to protect against heart disease, but that lowering the level might be beneficial. A drug that does this is already on the market for treatment of acromegaly, a thickening of the bones caused by excessive growth hormone. “Our underlying hypothesis is that this drug would prolong life span,” Longo said. He said he was not taking the drug, called pegvisomant or Somavert, which is very hard to obtain. |
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